Something I learned today about vMotion & Cisco switches
When VMware says that you should put your vMotion interfaces on separate (isolated) networks from your Management adapters, they REALLY mean it. Always, always, keep your vMotion network on a dedicated nic, and on a separate isolated network. Google shows me that others have seen something similar as well.
http://www.vmadmin.info/2011/04/vmotion-unicast-flood-esxi.html
http://www.vmadmin.info/2011/04/vmotion-unicast-flood-esxi.html